Tumour localization of monoclonal antibody against a rat mammary carcinoma and suppression of tumour growth with adriamycin-antibody conjugates

Monoclonal antibody to the rat mammary carcinoma Sp4 isolated from hybridoma supernatants and labelled with super(125)I showed preferential in vivo localization into subcutaneous growths of Sp4 compared with normal tissues and a range of other transplanted tumours. No specific localization was seen...

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Published in:Cancer Immunology Immunotherapy 1982-02, Vol.12 (2), p.125-134
Main Authors: Pimm, MalcolmV, Jones, JeanA, Price, MichaelR, Middle, JohnG, Embleton, MichaelJ, Baldwin, RobertW
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Language:English
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container_end_page 134
container_issue 2
container_start_page 125
container_title Cancer Immunology Immunotherapy
container_volume 12
creator Pimm, MalcolmV
Jones, JeanA
Price, MichaelR
Middle, JohnG
Embleton, MichaelJ
Baldwin, RobertW
description Monoclonal antibody to the rat mammary carcinoma Sp4 isolated from hybridoma supernatants and labelled with super(125)I showed preferential in vivo localization into subcutaneous growths of Sp4 compared with normal tissues and a range of other transplanted tumours. No specific localization was seen with super(125)I-labelled normal rat immunoglobulin. Adriamycin conjugated to monoclonal antibody significantly retarded Sp4 tumour growth at 1/25th of the effective dose of the free drug, and in some cases brought about total tumour regression. Normal rat immunoglobulin-adriamycin conjugates were relatively ineffective. These studies indicate that monoclonal antibody directed against tumour cell surface antigens may be highly effective for tumour targeting of therapeutic agents.
doi_str_mv 10.1007/BF00205370
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title Tumour localization of monoclonal antibody against a rat mammary carcinoma and suppression of tumour growth with adriamycin-antibody conjugates
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