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Serum markers of oxidative stress and endometriosis

To assess the changes secondary to chronic inflammation in women with and without pelvic endometriosis by the determination of serum thiols and carbonyls. Sixty-seven women with endometriosis consecutively submitted to laparoscopy and 41 women without endometriosis consecutively submitted to tubal l...

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Published in:	Clinical and experimental obstetrics & gynecology 2014-01, Vol.41 (4), p.371-374
Main Authors:	Rosa e Silva, J C, do Amara, V Ferreira, Mendonça, J L, Rosa e Silva, A C Japur de Sá, Nakao, L S, Poli Neto, O B, Ferriani, R A
Format:	Article
Language:	English
Subjects:	Adult Biomarkers - blood Endometriosis - blood Endometriosis - physiopathology Endometriosis - surgery Female Humans Laparoscopy Lipid Peroxidation - physiology Oxidative Stress - physiology Sensitivity and Specificity Sulfhydryl Compounds - blood
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container_issue	4
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container_title	Clinical and experimental obstetrics & gynecology
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creator	Rosa e Silva, J C do Amara, V Ferreira Mendonça, J L Rosa e Silva, A C Japur de Sá Nakao, L S Poli Neto, O B Ferriani, R A
description	To assess the changes secondary to chronic inflammation in women with and without pelvic endometriosis by the determination of serum thiols and carbonyls. Sixty-seven women with endometriosis consecutively submitted to laparoscopy and 41 women without endometriosis consecutively submitted to tubal ligation (control group) were selected. Serum levels of total thiols and carbonyls were determined in both groups. Patients with endometriosis had significantly lower thiol levels than controls (342.37 +/- 142.09 microM vs 559.60 +/- 294.05 microM) (p < 0.001), as well as significantly lower carbonyl levels (8.97 +/- 3.76 microM vs 16.40 +/- 9.26 microM) (p < 0.001). Other clinical characteristics were not associated with changes in marker levels. The cutoff point established by the ROC curve was 396.44 microM for the thiols, with 73.1% sensitivity and 80.5% specificity, and 14.9 microM for the carbonyls, with 94% sensitivity and 51.2% specificity. The serum thiol levels revealed an increase in oxidative stress related to the development of pelvic endometriosis.
doi_str_mv	10.12891/ceog16992014
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Sixty-seven women with endometriosis consecutively submitted to laparoscopy and 41 women without endometriosis consecutively submitted to tubal ligation (control group) were selected. Serum levels of total thiols and carbonyls were determined in both groups. Patients with endometriosis had significantly lower thiol levels than controls (342.37 +/- 142.09 microM vs 559.60 +/- 294.05 microM) (p < 0.001), as well as significantly lower carbonyl levels (8.97 +/- 3.76 microM vs 16.40 +/- 9.26 microM) (p < 0.001). Other clinical characteristics were not associated with changes in marker levels. The cutoff point established by the ROC curve was 396.44 microM for the thiols, with 73.1% sensitivity and 80.5% specificity, and 14.9 microM for the carbonyls, with 94% sensitivity and 51.2% specificity. 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subjects	Adult Biomarkers - blood Endometriosis - blood Endometriosis - physiopathology Endometriosis - surgery Female Humans Laparoscopy Lipid Peroxidation - physiology Oxidative Stress - physiology Sensitivity and Specificity Sulfhydryl Compounds - blood
title	Serum markers of oxidative stress and endometriosis
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