Strippers reveal their depressing secrets: removing AMPA receptors

How do microglia regulate synaptic function? In this issue of Neuron, Zhang et al. (2014) describe a novel form of long-term depression of AMPA receptor-mediated synaptic transmission in the hippocampus involving the activation of microglia.

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2014-04, Vol.82 (1), p.3-6
Main Authors: Collingridge, Graham L, Peineau, Stephane
Format: Article
Language:English
Subjects:
Animals
Cytokines
Disease
Hippocampus - physiology
Hypoxia
Information storage
Long-Term Synaptic Depression - physiology
Macrophage-1 Antigen - metabolism
Microglia - metabolism
NADPH Oxidases - metabolism
Neurons
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Description
Summary:How do microglia regulate synaptic function? In this issue of Neuron, Zhang et al. (2014) describe a novel form of long-term depression of AMPA receptor-mediated synaptic transmission in the hippocampus involving the activation of microglia.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2014.03.019