AHR: Making the Keratinocytes Thick Skinned

Dysregulated signals from the external environment and/or the internal milieu of the skin can lead to pathological conditions such as psoriasis. Di Meglio et al. (2014) show that the environment-responsive transcription factor AhR acts in keratinocytes to suppress psoriatic lesions.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2014-06, Vol.40 (6), p.863-864
Main Author: Colonna, Marco
Format: Article
Language:English
Subjects:
Animals
Basic Helix-Loop-Helix Transcription Factors - immunology
Cytokines
Enzymes
Gene expression
Humans
Immune system
Inflammation - immunology
Ligands
Metabolites
Polycyclic aromatic hydrocarbons
Psoriasis
Psoriasis - immunology
Receptors, Aryl Hydrocarbon - immunology
Transcription factors
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Description
Summary:Dysregulated signals from the external environment and/or the internal milieu of the skin can lead to pathological conditions such as psoriasis. Di Meglio et al. (2014) show that the environment-responsive transcription factor AhR acts in keratinocytes to suppress psoriatic lesions.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2014.06.001