Costimulatory TNFR family members in control of viral infection: Outstanding questions

Highlights • TNFR family members can have differential importance in different viral infections. • Viral infection modulates TNF family receptors, ligands and signaling adaptors. • The unique signals induced by each TNFR family member remain to be fully defined. • The role of a number of TNFRs on in...

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Bibliographic Details
Published in:Seminars in immunology 2014-06, Vol.26 (3), p.210-219
Main Authors: Mbanwi, Achire N, Watts, Tania H
Format: Article
Language:English
Subjects:
4-1BB
Allergy and Immunology
Animals
CD27
Cytomegalovirus
GITR
Humans
Influenza
LCMV
OX40
Receptors, Tumor Necrosis Factor - agonists
Receptors, Tumor Necrosis Factor - metabolism
T cell
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Vaccinia
Virus Diseases - drug therapy
Virus Diseases - immunology
Virus Diseases - pathology
Virus Diseases - virology
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Description
Summary:Highlights • TNFR family members can have differential importance in different viral infections. • Viral infection modulates TNF family receptors, ligands and signaling adaptors. • The unique signals induced by each TNFR family member remain to be fully defined. • The role of a number of TNFRs on innate cells during viral infection is poorly understood. • Manipulation of TNFR family signaling can exacerbate or ameliorate viral disease.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2014.05.001