Cell origins and significance of IL-17 in malignant pleural effusion

Purpose T cells are dominant in the immune regulation of malignant pleural effusion (MPE). However, it is unclear about the role of IL-17+ T cells, particularly for IL-17+CD8+ Tc17 cells in antitumor immunity. This retrospective study is aimed at evaluating the prognostic significance of IL-17+ T ce...

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Bibliographic Details
Published in:Clinical & translational oncology 2014-09, Vol.16 (9), p.807-813
Main Authors: Gong, Y., Chen, S. X., Gao, B. A., Yao, R. C., Guan, L.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
CD8-Positive T-Lymphocytes - immunology
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Humans
Immunohistochemistry
Interleukin-17 - biosynthesis
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Pleural Effusion, Malignant - immunology
Research Article
Retrospective Studies
T-Lymphocyte Subsets - immunology
Th17 Cells - immunology
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Summary:Purpose T cells are dominant in the immune regulation of malignant pleural effusion (MPE). However, it is unclear about the role of IL-17+ T cells, particularly for IL-17+CD8+ Tc17 cells in antitumor immunity. This retrospective study is aimed at evaluating the prognostic significance of IL-17+ T cells in patients with MPE. Methods The frequency of IL-17+CD4+ Th17 and IL-17+CD8+ Tc17 cells in peripheral blood (PB), pleural fluids (PF), and tumor tissues in 24 patients undergoing thoracoscopy was determined by flow cytometry, immunohistochemistry, and ELISA. The association among the different measures was analyzed by Spearman’s correlation tests. Results The percentages of PF Th17 and Tc17 cells were significantly higher than those in the PB of MPE patients and healthy controls ( p  
ISSN:1699-048X
1699-3055
DOI:10.1007/s12094-013-1152-8