Early life permethrin exposure leads to hypervitaminosis D, nitric oxide and catecholamines impairment

•Fifteen days of permethrin treatment during the early life has long-term effects.•Treatment increases 25-hydroxy-vitamin D, NO and sodium levels in plasma.•Treatment decreases calcium, adrenaline, noradrenaline and urea levels in plasma.•Increased noradrenaline level was detected in urine of treate...

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Published in:Pesticide biochemistry and physiology 2013-09, Vol.107 (1), p.93-97
Main Authors: Fedeli, Donatella, Carloni, Manuel, Nasuti, Cinzia, Gambini, Anna, Scocco, Vitangelo, Gabbianelli, Rosita
Format: Article
Language:English
Subjects:
25-Hydroxy-vitamin D
Aging - blood
Aging - urine
Animals
Animals, Newborn
Calcium
Calcium - blood
Calcium - urine
Catecholamines
Catecholamines - blood
Catecholamines - urine
Early life permethrin treatment
Female
Glucose - analysis
Hydrocortisone - blood
Insecticides - toxicity
Male
Nitric Oxide - blood
Permethrin - toxicity
Potassium - blood
Potassium - urine
Rat
Rats, Wistar
Sodium - blood
Sodium - urine
Urea - blood
Vitamin D - blood
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Summary:•Fifteen days of permethrin treatment during the early life has long-term effects.•Treatment increases 25-hydroxy-vitamin D, NO and sodium levels in plasma.•Treatment decreases calcium, adrenaline, noradrenaline and urea levels in plasma.•Increased noradrenaline level was detected in urine of treated group.•Decreased calcium, sodium and adrenaline levels were in urine of treated rats. The aim of this study is to gain more knowledge on the impact of early life pesticide exposure on premature aging. The effect of a low dose of the insecticide permethrin administered to rats during early life (1/50 LD50, from 6th to 21st day of life) was analyzed by measuring some metabolites in plasma and urine of 500-day-old animals. Significant differences in early life treated rats compared to the control group were found in the plasma levels of Ca++, Na+, 25-hydroxy-vitamin D, adrenaline, noradrenaline, nitric oxide, cholesterol and urea while in urine only Na+ content was different. These results add information on the impact of permethrin during the neonatal period, supporting the evidence that early life environmental exposure to xenobiotics has long-term effects, inducing modifications in adulthood that can be revealed by the analysis of some macroelements, metabolites and catecholamines in plasma, when rats are 500days old.
ISSN:0048-3575
1095-9939
DOI:10.1016/j.pestbp.2013.05.010