The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma

Highlights • Low-EMX2 expression is a negative prognostic factor in mesothelioma. • High-EMX2 expression is associated with no benefice of neoadjuvant chemotherapy. • EMX2 expression is associated with IMIG stage and smoking history.

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2014-09, Vol.85 (3), p.465-471
Main Authors: Giroux Leprieur, Etienne, Hirata, Tomomi, Mo, Minli, Chen, Zhao, Okamoto, Junichi, Clement, Genevieve, Li, Hui, Wislez, Marie, Jablons, David M, He, Biao
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers
Combined Modality Therapy
Disease Progression
EMX2
Female
Gene Expression
Hematology, Oncology and Palliative Medicine
Homeodomain Proteins - genetics
Humans
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - therapy
Male
Medical sciences
Mesothelioma
Mesothelioma - genetics
Mesothelioma - mortality
Mesothelioma - pathology
Mesothelioma - therapy
Mesothelioma, Malignant
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoadjuvant chemotherapy
Neoplasm Staging
Overall survival
Pleural Neoplasms - genetics
Pleural Neoplasms - mortality
Pleural Neoplasms - pathology
Pleural Neoplasms - therapy
Pneumology
Predictive marker
Prognosis
Progression-free survival
Pulmonary/Respiratory
Transcription Factors - genetics
Tumors
Tumors of the respiratory system and mediastinum
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Description
Summary:Highlights • Low-EMX2 expression is a negative prognostic factor in mesothelioma. • High-EMX2 expression is associated with no benefice of neoadjuvant chemotherapy. • EMX2 expression is associated with IMIG stage and smoking history.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2014.06.018