Parental exposure to X rays and chemicals induces heritable tumours and anomalies in mice

Although radiation and various chemicals are known to produce mutations, there is a paucity of information on the production of germ-line mutations leading to heritable tumours and anomalies. I now report a significant and large increase in such tumours and anomalies following treatment of ICR paren...

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Bibliographic Details
Published in:Nature (London) 1982-04, Vol.296 (5857), p.575-577
Main Author: Nomura, Taisei
Format: Article
Language:English
Subjects:
Animals
Female
Genes, Dominant
Humanities and Social Sciences
letter
Lung Neoplasms - genetics
Male
Mice
multidisciplinary
Mutation
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - genetics
Neoplasms, Radiation-Induced - genetics
Oocytes - radiation effects
Science
Science (multidisciplinary)
Spermatogonia - radiation effects
Spermatozoa - radiation effects
Urethane
X-Rays
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Summary:Although radiation and various chemicals are known to produce mutations, there is a paucity of information on the production of germ-line mutations leading to heritable tumours and anomalies. I now report a significant and large increase in such tumours and anomalies following treatment of ICR parent mice with X rays and urethane. About 90% of the induced tumours were in the lung, and were inherited as if they were dominant mutations with about 40% penetrance.
ISSN:0028-0836
1476-4687
DOI:10.1038/296575a0