Relationship between sister chromatid exchanges and structural chromosome aberrations in lymphocytes of 100 individuals

Sister chromatid exchanges and structural chromosome aberrations, i.e. chromatid and isochromatid agps, chromatid breaks and interchanges, acentric fragments, pericentric inversions, marker chromosomes, rings and dicentric chromosomes, were analyzed in peripheral blood lymphocytes of 100 individuals...

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Bibliographic Details
Published in:Hereditas 1982-01, Vol.97 (2), p.237-245
Main Authors: Hedner, K, Högstedt, B, Kolnig, A M, Mark-Vendel, E, Strömbeck, B, Mitelman, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alcoholism - genetics
Chromosome Aberrations
Crossing Over, Genetic - drug effects
Epoxy Resins - toxicity
Ethylene Oxide - toxicity
Female
Humans
Lymphocytes - drug effects
Lymphocytes - ultrastructure
Male
Middle Aged
Occupations
Sister Chromatid Exchange - drug effects
Solvents - toxicity
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Summary:Sister chromatid exchanges and structural chromosome aberrations, i.e. chromatid and isochromatid agps, chromatid breaks and interchanges, acentric fragments, pericentric inversions, marker chromosomes, rings and dicentric chromosomes, were analyzed in peripheral blood lymphocytes of 100 individuals. The subjects belonged to six different groups: 22 factory workers occupationally exposed to ethylene oxide; 17 factory workers occupationally exposed to epoxy resins; 13 factory workers occupationally exposed to organic solvents, mainly toluene; 7 bus drivers; 6 chronic alcoholics; and 35 factory workers with no occupational exposure to any known genotoxicant. In the total material there was a highly significant correlation between the number of each structural aberration type recorded and the number of cells with such aberrations.
ISSN:0018-0661
1601-5223
DOI:10.1111/j.1601-5223.1982.tb00768.x