Plasma 8-iso-Prostaglandin F2α concentrations and outcomes after acute intracerebral hemorrhage

• Published in: Clinica chimica acta 2014-11, Vol.437, p.141-146
• Main Authors: Du, Quan, Yu, Wen-Hua, Dong, Xiao-Qiao, Yang, Ding-Bo, Shen, Yong-Feng, Wang, Hao, Jiang, Li, Du, Yuan-Feng, Zhang, Zu-Yong, Zhu, Qiang, Che, Zhi-Hao, Liu, Qun-Jie
• Format: Article
• Language: English
• Subjects: 8-Iso-Prostaglandin F2α; Acute Disease; Aged; Biomarkers - blood; Cerebral Hemorrhage - blood; Cerebral Hemorrhage - diagnosis; Cerebral Hemorrhage - mortality; Dinoprost - analogs & derivatives; Dinoprost - blood; Female; Follow-Up Studies; Functional outcome; Humans; Intracerebral hemorrhage; Male; Middle Aged; Mortality; Mortality - trends; Oxidative stress; Severity; Stroke - blood; Stroke - diagnosis; Stroke - mortality; Treatment Outcome
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2014.07.014

Higher plasma 8-iso-Prostaglandin F2α concentrations have been associated with poor outcome of severe traumatic brain injury. We further investigated the relationships between plasma 8-iso-Prostaglandin F2α concentrations and clinical outcomes in patients with acute intracerebral hemorrhage. Plasma 8-iso-Prostaglandin F2α concentrations of 128 consecutive patients and 128 sex- and gender-matched healthy subjects were measured by enzyme-linked immunosorbent assay. We assessed their relationships with disease severity and clinical outcomes including 1-week mortality, 6-month mortality and unfavorable outcome (modified Rankin Scale score>2). Plasma 8-iso-Prostaglandin F2α concentrations were substantially higher in patients than in healthy controls. Plasma 8-iso-Prostaglandin F2α concentrations were positively associated with National Institutes of Health Stroke Scale (NIHSS) scores and hematoma volume using a multivariate linear regression. It emerged as an independent predictor for clinical outcomes of patients using a forward stepwise logistic regression. ROC curves identified the predictive values of plasma 8-iso-Prostaglandin F2α concentrations, and found its predictive value was similar to NIHSS scores and hematoma volumes. However, it just numerically added the predictive values of NIHSS score and hematoma volume. Increased plasma 8-iso-Prostaglandin F2α concentrations are associated with disease severity and clinical outcome after acute intracerebral hemorrhage. •Plasma 8-iso-Prostaglandin F2α levels are elevated after acute intracerebral hemorrhage.•Plasma 8-iso-Prostaglandin F2α levels are highly associated with the severity of acute intracerebral hemorrhage.•Plasma 8-iso-Prostaglandin F2α levels independently predict clinical outcome of acute intracerebral hemorrhage.•Plasma 8-iso-Prostaglandin F2α levels have high predictive values for clinical outcome of acute intracerebral hemorrhage.