Epicardial fat tissue thickness is correlated with diminished levels of co-enzyme Q10, a major antioxidant molecule among hemodialysis patients

• Published in: Clinical biochemistry 2014-09, Vol.47 (13-14), p.1231-1234
• Main Authors: Macunluoglu, Beyza, Atakan, Aydin, Ari, Elif, Kaya, Yüksel, Kaspar, Cigdem, Demir, Halit, Alp, Hamit Hakan
• Format: Article
• Language: English
• Subjects: Adipose Tissue - diagnostic imaging; Adipose Tissue - physiopathology; Adult; Antioxidants - metabolism; Cardiovascular disease; Cardiovascular Diseases - blood; Cardiovascular Diseases - diagnostic imaging; Cardiovascular Diseases - physiopathology; Carotid Arteries - diagnostic imaging; Carotid Arteries - physiopathology; Carotid Intima-Media Thickness; Case-Control Studies; Coenzyme-Q10; Echocardiography - methods; Epicardial fat tissue; Female; Hemodialysis; Humans; Male; Middle Aged; Pericardium - diagnostic imaging; Pericardium - physiopathology; Renal Dialysis - methods; Risk Factors; Ubiquinone - analogs & derivatives; Ubiquinone - blood
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2014.05.057

Accelerated atherosclerosis is the major cause of mortality in patients on chronic maintenance hemodialysis (HD). Epicardial fat tissue (EFT) is a new risk factor in cardiovascular disease (CVD). The aim of this study was to evaluate the relation between plasma coenzyme Q10 levels (Co-Q10) which is a potent physiologic antioxidant and EFT thickness in HD patients. Seventy one chronic HD patients and 65 age and sex matched healthy individuals were included in the study. Plasma Co-Q10 levels were performed by high-performance liquid chromatography (HPLC) measurements. EFT was measured by transthoracic echocardiograpy (TTE) performed with a VIVID 7 instrument. Plasma Co-Q10 levels (1.36±0.43 vs 2.53±0.55, p