Protection of Mice from Fatal Herpes Simplex Virus Type 1 Infection by Adoptive Transfer of Cloned Virus-specific and H-2-restricted Cytotoxic T Lymphocytes

Institut für Medizinische Mikrobiologie und Immunologie der Universität Bonn, 5300 Bonn-Venusberg, Federal Republic of Germany A cloned culture of secondary anti-herpes simplex virus (anti-HSV) cytotoxic T lymphocytes (CTL) generated in vitro when adoptively transferred to intact or cyclophosphamide...

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Bibliographic Details
Published in:Journal of general virology 1983-02, Vol.64 (2), p.443-447
Main Authors: Sethi, K.K, Omata, Y, Schneweis, K. E
Format: Article
Language:English
Subjects:
Animals
Clone Cells
Cyclophosphamide - pharmacology
Female
Herpes Simplex - immunology
herpes simplex virus 1
Immunization, Passive
Mice
Mice, Inbred BALB C
T-Lymphocytes, Cytotoxic - immunology
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Summary:Institut für Medizinische Mikrobiologie und Immunologie der Universität Bonn, 5300 Bonn-Venusberg, Federal Republic of Germany A cloned culture of secondary anti-herpes simplex virus (anti-HSV) cytotoxic T lymphocytes (CTL) generated in vitro when adoptively transferred to intact or cyclophosphamide (CP) pretreated syngeneic mice protected the recipients from death following intraperitoneal infection with HSV-1. This in vivo protective effect conferred by anti-HSV CTL was virus-specific and H-2K/D-restricted. Twenty-four h after HSV-1 infection of BALB/c mice (intact or CP-pretreated) relatively high levels of serum interferon- were observed in the recipients of syngeneic anti-HSV CTL and this event may explain, at least in part, the CTL-mediated protective effect. Keywords: HSV-1, cytotoxic T lymphocytes, protection Received 21 July 1982; accepted 28 September 1982.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-64-2-443