Role of fluorodeoxyglucose positron emission tomography (FDG PET)‐computed tomography (CT) in the staging of bladder cancer

Objective To determine whether to use 18F‐fluorodeoxyglucose positron emission tomography (FDG PET) scans in the preoperative staging of bladder cancer (BC). Patients and Methods In all, 233 patients with muscle‐invasive BC (MIBC) or high‐risk non‐MIBC being considered for radical cystectomy (RC) be...

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Bibliographic Details
Published in:BJU international 2014-09, Vol.114 (3), p.389-395
Main Authors: Goodfellow, Henry, Viney, Zaid, Hughes, Paul, Rankin, Sheila, Rottenberg, Giles, Hughes, Simon, Evison, Felicity, Dasgupta, Prokar, O'Brien, Timothy, Khan, Muhammad Shamim
Format: Article
Language:English
Subjects:
Abdomen - diagnostic imaging
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Bladder cancer
Cost-Benefit Analysis
Cystectomy
FDG PET/CT
Female
Fluorodeoxyglucose F18
Follow-Up Studies
Humans
Lymphatic Metastasis
Male
Medical imaging
Medical sciences
Metastasis
Middle Aged
Multimodal Imaging - economics
Multimodal Imaging - methods
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasm Staging
Nephrology. Urinary tract diseases
Patient Selection
Pelvis - diagnostic imaging
positron emission tomography
Positron-Emission Tomography - economics
preoperative staging
Prognosis
Radiopharmaceuticals
Sensitivity and Specificity
Thorax - diagnostic imaging
Tomography
Tomography, X-Ray Computed
Tumors
Tumors of the urinary system
Urinary Bladder Neoplasms - diagnostic imaging
Urinary Bladder Neoplasms - pathology
Urinary tract. Prostate gland
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Summary:Objective To determine whether to use 18F‐fluorodeoxyglucose positron emission tomography (FDG PET) scans in the preoperative staging of bladder cancer (BC). Patients and Methods In all, 233 patients with muscle‐invasive BC (MIBC) or high‐risk non‐MIBC being considered for radical cystectomy (RC) between 2005 and 2011 had FDG‐PET and computed tomography (CT) of the chest, abdomen and pelvis to assess for pelvic lymph node (LN) involvement or distant metastases. Sensitivity and specificity for detecting pelvic LN involvement was determined by comparing the results of the scans to the histopathology reports in patients undergoing RC. These parameters for distant metastases were determined from biopsy results or follow‐up imaging. In patients who did not undergo RC, follow‐up imaging was used to evaluate the sensitivity and specificity. Patients were excluded from analysis if they either had neoadjuvant chemotherapy or had
ISSN:1464-4096
1464-410X
DOI:10.1111/bju.12608