Late‐onset cerebellar abiotrophy in a Labrador Retriever

CASE REPORT: A 5‐year‐old female spayed Labrador Retriever was examined for a hindlimb gait abnormality. Initial neurological examination was consistent with vestibular dysfunction. Over the course of 1 year, signs progressed to reflect cerebellar ataxia, vertical nystagmus and delayed postural reac...

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Bibliographic Details
Published in:Australian veterinary journal 2014-09, Vol.92 (9), p.339-342
Main Authors: Bertalan, A, Glass, EN, Kent, M, De LaHunta, A, Bradley, C
Format: Article
Language:English
Subjects:
Age of Onset
algorithms
Animals
Brain
brain stem
case studies
cerebellar abiotrophy
Cerebellar Ataxia - diagnostic imaging
Cerebellar Ataxia - physiopathology
cerebellar cortical degeneration
cerebellum
ceroid lipofuscinosis
Dog Diseases - diagnostic imaging
Dog Diseases - physiopathology
Dogs
Fatal Outcome
Female
gait
Histocytochemistry
histopathology
image analysis
Labrador Retriever
Labrador Retrievers
magnetic resonance imaging
Magnetic Resonance Imaging - veterinary
Medical treatment
neurons
Purkinje neurone degeneration
Radiography
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Summary:CASE REPORT: A 5‐year‐old female spayed Labrador Retriever was examined for a hindlimb gait abnormality. Initial neurological examination was consistent with vestibular dysfunction. Over the course of 1 year, signs progressed to reflect cerebellar ataxia, vertical nystagmus and delayed postural reactions in all limbs. At the initial examination, subjective evaluation of magnetic resonance imaging scan of the brain was considered normal. Repeat imaging at 1 year after initial examination revealed a reduction in the size of the cerebellum. Retrospectively, the size of the cerebellum on the initial MRI was small when assessed using an objective measurement algorithm. Postmortem histopathological evaluation of the brain showed diffuse degeneration of Purkinje cell neurones with secondary granule cell loss in the cerebellum, in addition to pigment inclusions in brainstem neurones. CONCLUSION: The clinical history and clinicopathological data are consistent with late‐onset cerebellar abiotrophy, which has not previously been described in this breed.
ISSN:0005-0423
1751-0813
DOI:10.1111/avj.12211