Synthesis of two peptide scorpion toxins and their use to investigate the aortic tissue regulation

The 37 amino acid residue polypeptides iberiotoxin and charybdotoxin, which contain three disulfide bridges, were chemically synthesized and characterized. The physiological effectiveness of these peptides was tested on rabbit aorta in vitro.

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1995, Vol.16 (7), p.1167-1172
Main Authors: Tóth, Gábor K., Pataricza, János, Janáky, Tamás, Mák, Marianna, Zarándi, Márta, Papp, Julius Gy, Penke, Botond
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - pharmacology
Amino Acid Sequence
Animals
Aorta - drug effects
Aortic tissue regulation
Buthidae
Charybdotoxin
Charybdotoxin - chemical synthesis
Charybdotoxin - pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Female
Formation of disulfide bridges
Iberiotoxin
In Vitro Techniques
Leiurus quinquestriatus
Male
Molecular Sequence Data
Muscle Contraction - drug effects
Muscle Tonus - drug effects
Peptides - chemical synthesis
Peptides - pharmacology
Phenylephrine - pharmacology
Rabbits
Scorpion toxins
Scorpiones
Solid-phase synthesis
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Description
Summary:The 37 amino acid residue polypeptides iberiotoxin and charybdotoxin, which contain three disulfide bridges, were chemically synthesized and characterized. The physiological effectiveness of these peptides was tested on rabbit aorta in vitro.
ISSN:0196-9781
1873-5169
DOI:10.1016/0196-9781(95)02007-J