Expression of the SmB' splicing protein in rodent cells capable of follwing an alternative RNA splicing pathway

The expression of the SmB and SmB' spliceosome proteins in a variety of cell types and tissues has been investigated. Although SmB is found in all cells studied, the SmB' protein is found only in a small number of rodent cell types. The presence of this protein is correlated with the abili...

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Bibliographic Details
Published in:FEBS letters 1989-01, Vol.243 (2), p.132-136
Main Authors: Sharpe, NG, Williams, D G, Norton, P, Latchman, D S
Format: Article
Language:English
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Summary:The expression of the SmB and SmB' spliceosome proteins in a variety of cell types and tissues has been investigated. Although SmB is found in all cells studied, the SmB' protein is found only in a small number of rodent cell types. The presence of this protein is correlated with the ability to utilize and alternative pathway of RNA splicing which is not available in most cell types. This is the first demonstration of tissue specific expression on a protein component of the spliceosome and suggests a role for SmB' in the regulation of some cases of alternative RNA splicing.
ISSN:0014-5793