The effect of selective noradrenergic denervation on thyrotropin secretion in the rat

The effect of DSP4 [N-(2-chloroethyl)-N-ethyl-2 bromobenzylamine], a neurotoxin which selectively lesions noradrenergic projections from the locus coeruleus, on thyrotropin (TSH) secretion was investigated in the rat. DSP4 treatment (60 mg/kg injected i.p. 10 days prior to experimentation) significa...

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Bibliographic Details
Published in:Neurochemical research 1990, Vol.15 (1), p.13-16
Main Authors: JAFFER, A, SEARSON, A, RUSSELL, V.A, TALJAARD, J. J. F
Format: Article
Language:English
Subjects:
Adrenergic Fibers - drug effects
Adrenergic Fibers - physiology
Animals
Benzylamines
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Hormones and neuropeptides. Regulation
Hypothalamus - metabolism
Hypothalamus - physiology
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Locus Coeruleus - drug effects
Locus Coeruleus - physiology
Male
Neurotoxins
Norepinephrine - metabolism
Norepinephrine - physiology
Rats
Rats, Inbred Strains
Thyrotropin - metabolism
Vertebrates: endocrinology
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Summary:The effect of DSP4 [N-(2-chloroethyl)-N-ethyl-2 bromobenzylamine], a neurotoxin which selectively lesions noradrenergic projections from the locus coeruleus, on thyrotropin (TSH) secretion was investigated in the rat. DSP4 treatment (60 mg/kg injected i.p. 10 days prior to experimentation) significantly decreased the noradrenaline (NA) content of the hippocampus, frontal cortex and hypothalamus of the rat brain. DSP4 treatment did not affect the clonidine (250 micrograms/kg, i.p ) or TSH-releasing-hormone (TRH 5 micrograms/kg i.v.) induced stimulation or the isoproterenol induced inhibition of TSH secretion in the rat. These results suggest that the noradrenergic projection from the locus coeruleus to the hypothalamus does not play a significant role in the regulation of TSH secretion. Furthermore, the noradrenergic deficiency did not give rise to the development of the abnormal TSH response to TRH administration which is frequently observed in depression.
ISSN:0364-3190
1573-6903
DOI:10.1007/bf00969178