Association of GABRA6 1519 T>C (rs3219151) and Synapsin II (rs37733634) gene polymorphisms with the development of idiopathic generalized epilepsy

Highlights • Evaluated association of GABRA6 T>C and Syn II A>G gene variants with IGE. • A significant association of these gene variants with IGE was observed. • Significant interaction between these genes was observed.

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Bibliographic Details
Published in:Epilepsy research 2014-10, Vol.108 (8), p.1267-1273
Main Authors: Prasad, D.K.V, Shaheen, Uzma, Satyanarayana, U, Prabha, T. Surya, Jyothy, A, Munshi, Anjana
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Child
Child, Preschool
Epilepsy, Generalized - diagnosis
Epilepsy, Generalized - epidemiology
Epilepsy, Generalized - genetics
Epileptogenesis
Female
Gamma-amino butyric acid (GABA)
Genetic Association Studies - methods
Gene–gene interaction
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Idiopathic generalized epilepsies
India - epidemiology
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Neurotransmitter
Polymorphism, Single Nucleotide - genetics
Receptors, GABA-A - genetics
Synapsin II
Synapsins - genetics
Young Adult
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Description
Summary:Highlights • Evaluated association of GABRA6 T>C and Syn II A>G gene variants with IGE. • A significant association of these gene variants with IGE was observed. • Significant interaction between these genes was observed.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2014.07.001