Early improvement in basophil sensitivity predicts symptom relief with grass pollen immunotherapy

• Published in: Journal of allergy and clinical immunology 2014-09, Vol.134 (3), p.741-744.e5
• Main Authors: Schmid, Johannes Martin, MD, Würtzen, Peter Adler, PhD, Dahl, Ronald, DrMedSci, Hoffmann, Hans Jürgen, PhD
• Format: Article
• Language: English
• Subjects: Allergens - immunology; Allergens - therapeutic use; Allergies; Allergy and Immunology; Antigens; Basophil Degranulation Test; Basophils - immunology; Biological and medical sciences; Desensitization, Immunologic - methods; Epitopes - immunology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunoglobulin E - immunology; Immunopathology; Immunotherapy; Injections, Subcutaneous; Medical sciences; Plasma; Poaceae; Pollen; Pollen - immunology; Predictive Value of Tests; Prognosis; Rhinitis, Allergic, Seasonal - diagnosis; Rhinitis, Allergic, Seasonal - immunology; Rhinitis, Allergic, Seasonal - therapy; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sensitivity and Specificity; Treatment Outcome
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2014.04.029

AIT induces specific non-IgE antibodies that compete with cell-bound IgE for allergen epitopes.1,2 Transient anergy induced in mast cells and basophil granulocytes during drug desensitization3 and during rush subcutaneous immunotherapy (SCIT) in vivo4 might offer protection until this adaptive immune response is mounted.5 The effector cell-associated response has rarely been addressed because it has been difficult to separate from the adaptive component.  Treatment group (n = 18) Control group (n = 6) Between groups[low *] 12 wk 52 wk 12 wk 52 wk 52 wk  P value  P value  P value  P value P value Maximum symptom score  -5.8 (-7.7 to -3.9)