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The prevalence of keratoconus in a young population in Mashhad, Iran
Purpose To determine the prevalence of keratoconus and some associated factors in the students of Mashhad University of Medical Sciences, Iran. Method In this cross sectional study, multistage cluster sampling was used to select the participants. All participants underwent retinoscopy, slit lamp exa...
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| Published in: | Ophthalmic & physiological optics 2014-09, Vol.34 (5), p.519-527 |
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| Main Authors: | , , , , , , , , |
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| Language: | English |
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| container_end_page | 527 |
| container_issue | 5 |
| container_start_page | 519 |
| container_title | Ophthalmic & physiological optics |
| container_volume | 34 |
| creator | Hashemi, Hassan Khabazkhoob, Mehdi Yazdani, Negareh Ostadimoghaddam, Hadi Norouzirad, Reza Amanzadeh, Kazem Miraftab, Mohammad Derakhshan, Akbar Yekta, AbbasAli |
| description | Purpose
To determine the prevalence of keratoconus and some associated factors in the students of Mashhad University of Medical Sciences, Iran.
Method
In this cross sectional study, multistage cluster sampling was used to select the participants. All participants underwent retinoscopy, slit lamp examination, topography with the TMS‐4 and corneal assessment with the Orbscan II. The diagnosis of keratoconus was based on both clinical evidence and the results of corneal imaging.
Results
Of 1280 selected students, 1073 agreed to participate in the study, and of those who agreed, 1027 fulfilled the inclusion criteria. 42.5% of the study population was male with a mean age of 26.1 ± 2.3 years. The prevalence of keratoconus was 2.5% (n = 26) (95% confidence interval, CI 1.6–3.5). Eighteen students (69%) had bilateral keratoconus. Imaging of the cornea revealed that 70% of the keratoconics had nipple cones and the remaining had asymmetric bow‐tie patterns. The prevalence of keratoconus was not significantly associated with age or gender (p > 0.05). In a multiple logistic regression model, family history (OR = 11.4, 95% CI: 2.5–51.3) and eye rubbing (OR = 6.3, 95% CI: 1.6–24.3) were significantly correlated with keratoconus.
Conclusions
These results taken together with recent studies in the area suggest that keratoconus may have a higher prevalence in the Middle East and Asia than in Western Countries. |
| doi_str_mv | 10.1111/opo.12147 |
| format | article |
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To determine the prevalence of keratoconus and some associated factors in the students of Mashhad University of Medical Sciences, Iran.
Method
In this cross sectional study, multistage cluster sampling was used to select the participants. All participants underwent retinoscopy, slit lamp examination, topography with the TMS‐4 and corneal assessment with the Orbscan II. The diagnosis of keratoconus was based on both clinical evidence and the results of corneal imaging.
Results
Of 1280 selected students, 1073 agreed to participate in the study, and of those who agreed, 1027 fulfilled the inclusion criteria. 42.5% of the study population was male with a mean age of 26.1 ± 2.3 years. The prevalence of keratoconus was 2.5% (n = 26) (95% confidence interval, CI 1.6–3.5). Eighteen students (69%) had bilateral keratoconus. Imaging of the cornea revealed that 70% of the keratoconics had nipple cones and the remaining had asymmetric bow‐tie patterns. The prevalence of keratoconus was not significantly associated with age or gender (p > 0.05). In a multiple logistic regression model, family history (OR = 11.4, 95% CI: 2.5–51.3) and eye rubbing (OR = 6.3, 95% CI: 1.6–24.3) were significantly correlated with keratoconus.
Conclusions
These results taken together with recent studies in the area suggest that keratoconus may have a higher prevalence in the Middle East and Asia than in Western Countries.</description><identifier>ISSN: 0275-5408</identifier><identifier>EISSN: 1475-1313</identifier><identifier>DOI: 10.1111/opo.12147</identifier><identifier>PMID: 25131846</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Age Factors ; Cluster Analysis ; Cross-Sectional Studies ; Female ; Humans ; Iran - epidemiology ; keratoconus ; Keratoconus - epidemiology ; Logistic Models ; Male ; Middle East ; Prevalence ; Risk Factors ; Sex Factors ; Young Adult</subject><ispartof>Ophthalmic & physiological optics, 2014-09, Vol.34 (5), p.519-527</ispartof><rights>2014 The Authors Ophthalmic & Physiological Optics © 2014 The College of Optometrists</rights><rights>2014 The Authors Ophthalmic & Physiological Optics © 2014 The College of Optometrists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3637-93a29681476b721cd5994ffc35ee74e941df5260adb17b41519916f12438ef573</citedby><cites>FETCH-LOGICAL-c3637-93a29681476b721cd5994ffc35ee74e941df5260adb17b41519916f12438ef573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25131846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashemi, Hassan</creatorcontrib><creatorcontrib>Khabazkhoob, Mehdi</creatorcontrib><creatorcontrib>Yazdani, Negareh</creatorcontrib><creatorcontrib>Ostadimoghaddam, Hadi</creatorcontrib><creatorcontrib>Norouzirad, Reza</creatorcontrib><creatorcontrib>Amanzadeh, Kazem</creatorcontrib><creatorcontrib>Miraftab, Mohammad</creatorcontrib><creatorcontrib>Derakhshan, Akbar</creatorcontrib><creatorcontrib>Yekta, AbbasAli</creatorcontrib><title>The prevalence of keratoconus in a young population in Mashhad, Iran</title><title>Ophthalmic & physiological optics</title><addtitle>Ophthalmic Physiol Opt</addtitle><description>Purpose
To determine the prevalence of keratoconus and some associated factors in the students of Mashhad University of Medical Sciences, Iran.
Method
In this cross sectional study, multistage cluster sampling was used to select the participants. All participants underwent retinoscopy, slit lamp examination, topography with the TMS‐4 and corneal assessment with the Orbscan II. The diagnosis of keratoconus was based on both clinical evidence and the results of corneal imaging.
Results
Of 1280 selected students, 1073 agreed to participate in the study, and of those who agreed, 1027 fulfilled the inclusion criteria. 42.5% of the study population was male with a mean age of 26.1 ± 2.3 years. The prevalence of keratoconus was 2.5% (n = 26) (95% confidence interval, CI 1.6–3.5). Eighteen students (69%) had bilateral keratoconus. Imaging of the cornea revealed that 70% of the keratoconics had nipple cones and the remaining had asymmetric bow‐tie patterns. The prevalence of keratoconus was not significantly associated with age or gender (p > 0.05). In a multiple logistic regression model, family history (OR = 11.4, 95% CI: 2.5–51.3) and eye rubbing (OR = 6.3, 95% CI: 1.6–24.3) were significantly correlated with keratoconus.
Conclusions
These results taken together with recent studies in the area suggest that keratoconus may have a higher prevalence in the Middle East and Asia than in Western Countries.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Cluster Analysis</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Iran - epidemiology</subject><subject>keratoconus</subject><subject>Keratoconus - epidemiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle East</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Young Adult</subject><issn>0275-5408</issn><issn>1475-1313</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kE9PwkAQxTdGI4ge_AKmR00sdLrdbntUVCQB0YjhuFnaqVRKt-5SlW_vIn9uzmFmMvm9l8kj5By8NtjqqEq1wYeAH5Cm7cwFCvSQND3f7izwogY5MebD8zzOeXRMGj6zRBSETXI3nqFTafySBZYJOipz5qjlUiWqrI2Tl450Vqou351KVXUhl7kq19ehNLOZTK-dvpblKTnKZGHwbDtb5O3hftx9dAejXr97M3ATGlLuxlT6cRjZD8Mp9yFJWRwHWZZQhsgDjANIM-aHnkynwKcBMIhjCDPwAxphxjhtkcuNb6XVZ41mKRa5SbAoZImqNgIYi9iaZha92qCJVsZozESl84XUKwGeWIcmbGjiLzTLXmxt6-kC0z25S8kCnQ3wnRe4-t9JjJ5HO0t3o8jNEn_2CqnnIuSUMzF56okJ3EYv0HsVQ_oLu-CDQA</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Hashemi, Hassan</creator><creator>Khabazkhoob, Mehdi</creator><creator>Yazdani, Negareh</creator><creator>Ostadimoghaddam, Hadi</creator><creator>Norouzirad, Reza</creator><creator>Amanzadeh, Kazem</creator><creator>Miraftab, Mohammad</creator><creator>Derakhshan, Akbar</creator><creator>Yekta, AbbasAli</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201409</creationdate><title>The prevalence of keratoconus in a young population in Mashhad, Iran</title><author>Hashemi, Hassan ; Khabazkhoob, Mehdi ; Yazdani, Negareh ; Ostadimoghaddam, Hadi ; Norouzirad, Reza ; Amanzadeh, Kazem ; Miraftab, Mohammad ; Derakhshan, Akbar ; Yekta, AbbasAli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3637-93a29681476b721cd5994ffc35ee74e941df5260adb17b41519916f12438ef573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Cluster Analysis</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Iran - epidemiology</topic><topic>keratoconus</topic><topic>Keratoconus - epidemiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle East</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashemi, Hassan</creatorcontrib><creatorcontrib>Khabazkhoob, Mehdi</creatorcontrib><creatorcontrib>Yazdani, Negareh</creatorcontrib><creatorcontrib>Ostadimoghaddam, Hadi</creatorcontrib><creatorcontrib>Norouzirad, Reza</creatorcontrib><creatorcontrib>Amanzadeh, Kazem</creatorcontrib><creatorcontrib>Miraftab, Mohammad</creatorcontrib><creatorcontrib>Derakhshan, Akbar</creatorcontrib><creatorcontrib>Yekta, AbbasAli</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmic & physiological optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashemi, Hassan</au><au>Khabazkhoob, Mehdi</au><au>Yazdani, Negareh</au><au>Ostadimoghaddam, Hadi</au><au>Norouzirad, Reza</au><au>Amanzadeh, Kazem</au><au>Miraftab, Mohammad</au><au>Derakhshan, Akbar</au><au>Yekta, AbbasAli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prevalence of keratoconus in a young population in Mashhad, Iran</atitle><jtitle>Ophthalmic & physiological optics</jtitle><addtitle>Ophthalmic Physiol Opt</addtitle><date>2014-09</date><risdate>2014</risdate><volume>34</volume><issue>5</issue><spage>519</spage><epage>527</epage><pages>519-527</pages><issn>0275-5408</issn><eissn>1475-1313</eissn><abstract>Purpose
To determine the prevalence of keratoconus and some associated factors in the students of Mashhad University of Medical Sciences, Iran.
Method
In this cross sectional study, multistage cluster sampling was used to select the participants. All participants underwent retinoscopy, slit lamp examination, topography with the TMS‐4 and corneal assessment with the Orbscan II. The diagnosis of keratoconus was based on both clinical evidence and the results of corneal imaging.
Results
Of 1280 selected students, 1073 agreed to participate in the study, and of those who agreed, 1027 fulfilled the inclusion criteria. 42.5% of the study population was male with a mean age of 26.1 ± 2.3 years. The prevalence of keratoconus was 2.5% (n = 26) (95% confidence interval, CI 1.6–3.5). Eighteen students (69%) had bilateral keratoconus. Imaging of the cornea revealed that 70% of the keratoconics had nipple cones and the remaining had asymmetric bow‐tie patterns. The prevalence of keratoconus was not significantly associated with age or gender (p > 0.05). In a multiple logistic regression model, family history (OR = 11.4, 95% CI: 2.5–51.3) and eye rubbing (OR = 6.3, 95% CI: 1.6–24.3) were significantly correlated with keratoconus.
Conclusions
These results taken together with recent studies in the area suggest that keratoconus may have a higher prevalence in the Middle East and Asia than in Western Countries.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25131846</pmid><doi>10.1111/opo.12147</doi><tpages>9</tpages></addata></record> |
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| source | Wiley |
| subjects | Adult Age Factors Cluster Analysis Cross-Sectional Studies Female Humans Iran - epidemiology keratoconus Keratoconus - epidemiology Logistic Models Male Middle East Prevalence Risk Factors Sex Factors Young Adult |
| title | The prevalence of keratoconus in a young population in Mashhad, Iran |
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