Anti-leucocyte common antigen (CD45) antibodies inhibit dendritic cell stimulation of CD4 and CD8 T-lymphocyte proliferation

Dendritic cells (DC) act as primary antigen-presenting cells and probably initiate T-cell responses via the formation of DC-T-cell clusters. Both DC and T cells express members of the leucocyte common (CD45) family of molecules as major cell membrane proteins. The possibility that the leucocyte comm...

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Bibliographic Details
Published in:Immunology 1990-01, Vol.69 (2), p.250-256
Main Authors: Prickett, TCR, Hart, DHJ
Format: Article
Language:English
Online Access:Get full text
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Summary:Dendritic cells (DC) act as primary antigen-presenting cells and probably initiate T-cell responses via the formation of DC-T-cell clusters. Both DC and T cells express members of the leucocyte common (CD45) family of molecules as major cell membrane proteins. The possibility that the leucocyte common antigens (LCA) play a functional role in the cellular events of a primary T-cell response was tested, by examining the effect of CD45 antibodies on the T-cell proliferative response induced by stimulating with allogeneic DC in the mixed leucocyte reaction (MLR).
ISSN:0019-2805