Expression of Ki-67, Oct-4, γ-tubulin and α-tubulin in human tooth development

Highlights • Proper patterning of cell proliferation enables growth of the tooth germ. • Decrease of proliferation correlates with differentiation of tooth cell lineages. • Shift from nuclear to cytoplasmic expression of Oct-4 influences cell differentiation. • Primary cilia signalling modulates dif...

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Bibliographic Details
Published in:Archives of oral biology 2014-11, Vol.59 (11), p.1119-1129
Main Authors: Kero, Darko, Novakovic, Josip, Vukojevic, Katarina, Petricevic, Josko, Kalibovic Govorko, Danijela, Biocina-Lukenda, Dolores, Saraga-Babic, Mirna
Format: Article
Language:English
Subjects:
Advanced Basic Science
Ameloblasts - metabolism
Cell Differentiation
Cell Proliferation
Dental Enamel - metabolism
Dentistry
Differentiation
Fluorescent Antibody Technique
Human tooth development
Humans
Immunoenzyme Techniques
Ki-67
Ki-67 Antigen - metabolism
Oct-4 protein
Octamer Transcription Factor-3 - metabolism
Odontogenesis - physiology
Tooth - embryology
Tooth - metabolism
Tooth Germ - metabolism
Tubulin - metabolism
α-Tubulin
γ-Tubulin
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Summary:Highlights • Proper patterning of cell proliferation enables growth of the tooth germ. • Decrease of proliferation correlates with differentiation of tooth cell lineages. • Shift from nuclear to cytoplasmic expression of Oct-4 influences cell differentiation. • Primary cilia signalling modulates differentiation of ameloblasts and odontoblasts.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2014.05.025