Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle

Identification of the HtrA inhibitor JO146 previously enabled us to demonstrate an essential function for HtrA during the mid-replicative phase of the Chlamydia trachomatis developmental cycle. Here we extend our investigations to other members of the Chlamydia genus. C. trachomatis isolates with di...

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Bibliographic Details
Published in:Microbes and infection 2014-08, Vol.16 (8), p.690-694
Main Authors: Patel, Pooja, De Boer, Leonore, Timms, Peter, Huston, Wilhelmina May
Format: Article
Language:English
Subjects:
Bacterial Proteins - antagonists & inhibitors
Bacterial Proteins - metabolism
Chlamydia
Chlamydia - enzymology
Chlamydia - growth & development
HtrA
Inhibitor
Microbial Viability - drug effects
Protease
Protease Inhibitors - metabolism
Serine Proteases - metabolism
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Summary:Identification of the HtrA inhibitor JO146 previously enabled us to demonstrate an essential function for HtrA during the mid-replicative phase of the Chlamydia trachomatis developmental cycle. Here we extend our investigations to other members of the Chlamydia genus. C. trachomatis isolates with distinct replicative phase growth kinetics showed significant loss of viable infectious progeny after HtrA was inhibited during the replicative phase. Mid-replicative phase addition of JO146 was also significantly detrimental to Chlamydia pecorum, Chlamydia suis and Chlamydia cavie. These data combined indicate that HtrA has a conserved critical role during the replicative phase of the chlamydial developmental cycle.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2014.07.003