Magnetic Resonance Imaging (MRI) Detection of the Murine Brain Response to Light: Temporal Differentiation and Negative Functional MRI Changes

Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4T. Howeve...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1996-06, Vol.93 (12), p.6037-6042
Main Authors: Huang, Wei, Pályka, Ildikó, Li, HaiFang, Eisenstein, Edward M., Volkow, Nora D., Springer, Charles S.
Format: Article
Language:English
Subjects:
Anatomy
Animals
Blood
Blood vessels
Brain
Brain - diagnostic imaging
Brain - physiology
Light
Magnetic Resonance Imaging
Male
Mice
Neurons
NMR
Nuclear magnetic resonance
Photic Stimulation
Pixels
Radiography
Rodents
Tissue oxygenation
Visual stimulation
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Description
Summary:Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4T. However, there are also two unusual aspects to our findings. (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates. (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex, another area displays decreased signal intensity upon stimulation.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.93.12.6037