Interferon-α or β potentiate platinum analogous in human glioblastoma cell lines

The effect of interferon-α or β on platinum analogues [cisplatin (CDDP) and carboplatin] cytotoxicity was studied in four glioblastoma cell lines (U373MG, T98G, A172 and U118Mg). All cell lines were strongly resistant to the cytotoxic effect of CDDP or carboplatin. Although both interferons were not...

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Bibliographic Details
Published in:Mutation research. Mutation research letters 1995, Vol.348 (3), p.131-135
Main Authors: Stanzione, Sabrina, Cimoli, Guido, Debernardis, Domizia, Michelotti, Andrea, Conte, PierFranco, Parodi, Silvio, Russo, Patrizia
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemical mutagenesis
DNA damage
Glioman
Interferons
Medical sciences
Platinum
Potentiation
Toxicology
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Summary:The effect of interferon-α or β on platinum analogues [cisplatin (CDDP) and carboplatin] cytotoxicity was studied in four glioblastoma cell lines (U373MG, T98G, A172 and U118Mg). All cell lines were strongly resistant to the cytotoxic effect of CDDP or carboplatin. Although both interferons were not cytotoxic in all cell lines, they were able to significantly increase the cell platinum-sensitivity. Specifically interferon-α increased the magnitude of CDDP-induced DNA interstrand crosslinks Our findings suggest that interferons are able to induce a very strong potentiation of platinum analogues cytotoxicity in drug-resistant human glioma cell lines
ISSN:0165-7992
DOI:10.1016/0165-7992(95)00057-7