Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: A systematic review and meta-analysis

Abstract We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592–5.294) pg/mL, des...

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Bibliographic Details
Published in:Journal of neuroimmunology 2014-09, Vol.274 (1), p.215-224
Main Authors: Bustamante, Alejandro, Sobrino, Tomás, Giralt, Dolors, García-Berrocoso, Teresa, Llombart, Victor, Ugarriza, Iratxe, Espadaler, Marc, Rodríguez, Noelia, Sudlow, Cathie, Castellanos, Mar, Smith, Craig J, Rodríguez-Yánez, Manuel, Waje-Andreassen, Ulrike, Tanne, David, Oto, Jun, Barber, Mark, Worthmann, Hans, Wartenberg, Katja E, Becker, Kyra J, Chakraborty, Baidarbhi, Oh, Seung-Hun, Whiteley, William N, Castillo, José, Montaner, Joan
Format: Article
Language:English
Subjects:
Allergy and Immunology
Biomarkers - blood
Humans
Individual participant data analysis
Interleukin-6
Interleukin-6 - blood
Interleukin-6 - immunology
Meta-analysis
Neurology
Outcome
Post-stroke infection
Predictive Value of Tests
Prognosis
Recovery of Function - immunology
Stroke
Stroke - diagnosis
Stroke - immunology
Stroke - metabolism
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Summary:Abstract We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592–5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR = 2.346 (1.814–3.033), p < 0.0001). However, the additional predictive value of IL-6 was moderate (IDI = 1.5%, NRI = 5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2014.07.015