Zinc alginate-carboxymethyl cashew gum microbeads for prolonged drug release: Development and optimization

Isoxsuprine HCl-loaded microbeads using sodium alginate (SA)-carboxymethyl cashew gum (CMCG) polymer-blends were developed through ionotropic-gelation technique using ZnSO4 as cross-linker. Effects of polymer-blend ratio and cross-linker concentration on drug encapsulation efficiency (DEE) and cumul...

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Bibliographic Details
Published in:International journal of biological macromolecules 2014-09, Vol.70, p.506-515
Main Authors: Das, Biswarup, Dutta, Sukrit, Nayak, Amit Kumar, Nanda, Upendranath
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - administration & dosage
Alginates - chemistry
Anacardium - chemistry
Analysis of Variance
Calorimetry, Differential Scanning
Carboxymethyl cashew gum
Chemistry, Pharmaceutical
Drug Carriers
Drug Delivery Systems
Drug Liberation
Glucuronic Acid - chemistry
Hexuronic Acids - chemistry
Isoxsuprine - administration & dosage
Isoxsuprine HCl
Microspheres
Particle Size
Plant Gums - chemistry
Sodium alginate
Spectroscopy, Fourier Transform Infrared
Zinc - chemistry
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Summary:Isoxsuprine HCl-loaded microbeads using sodium alginate (SA)-carboxymethyl cashew gum (CMCG) polymer-blends were developed through ionotropic-gelation technique using ZnSO4 as cross-linker. Effects of polymer-blend ratio and cross-linker concentration on drug encapsulation efficiency (DEE) and cumulative drug release at 7h (R7h) were optimized by 32 factorial design. Optimized microbeads were of excellent combination of high DEE (79.92±2.51%) and suitable sustained drug release pattern over a prolonged period of 7h (58.67±2.26%). The microbead surface morphology was analyzed by SEM. The physical state of isoxsuprine HCl within the optimized microbead matrix was analyzed by FTIR and DSC. In vitro isoxsuprine HCl release from alginate-CMCG microbeads in phosphate buffer (pH, 6.8) showed prolonged sustained drug release and Korsmeyer-Peppas model (R2=0.9959–0.9992) over 7h.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2014.07.030