Evidence for the involvement of nitric oxide in the antinociceptive effect of ketorolac

• Published in: European journal of pharmacology 1995-04, Vol.277 (2), p.281-284
• Main Authors: Granados-Soto, Vinicio, Flores-Murrieta, Francisco J., Castañeda-Hernández, Gilberto, López-Muñoz, Francisco J.
• Format: Article
• Language: English
• Subjects: Analgesia; Analgesics; Analgesics, Non-Narcotic - administration & dosage; Analgesics, Non-Narcotic - pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Arginine - analogs & derivatives; Arginine - pharmacology; Biological and medical sciences; Cartilage, Articular - drug effects; Cartilage, Articular - metabolism; Dipyrone; Dipyrone - pharmacology; Female; Hindlimb; Ketorolac; Ketorolac tromethamine; Medical sciences; Neuropharmacology; NG-Nitro- l-arginine methyl ester; NG-Nitroarginine Methyl Ester; Nitric oxide (NO); Nitric Oxide - antagonists & inhibitors; Pain Measurement; Pharmacology. Drug treatments; Rats; Rats, Wistar; Tolmetin - administration & dosage; Tolmetin - analogs & derivatives; Tolmetin - pharmacology; Uric Acid - toxicity
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/0014-2999(95)00123-3

The involvement of nitric oxide in the antinociception produced by ketorolac was assessed using the pain-induced functional impairment model in the rat: 800 μg of N G-nitro- l-arginine methyl ester, an inhibitor of nitric oxide synthesis, or saline was injected intra-articularly in a hind limb joint previously injured with uric acid. Animals then received ketorolac, dipyrone or no drug. Ketorolac and dipyrone produced a significant antinociceptive effect which was reduced by pretreatment with N G-nitro- l-arginine methyl ester, but not with saline. It is concluded that the antinociceptive effect of both drugs involves the local participation of nitric oxide.