Airflow-directed in situelectrospinning of a medical glue of cyanoacrylate for rapid hemostasis in liver resection

Rapid hemostasis of solitary organs is still a big challenge in surgical procedures or after major trauma in both civilians and on the battlefield. Here, we report the first use of an airflow-directed in situelectrospinning method to precisely and homogeneously deposit a medical glue of n-octyl-2-cy...

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Bibliographic Details
Published in:Nanoscale 2014-06, Vol.6 (14), p.7792-7798
Main Authors: Jiang, Kai, Long, Yun-Ze, Chen, Zhao-Jun, Liu, Shu-Liang, Huang, Yuan-Yuan, Jiang, Xingyu, Huang, Zhi-Qiang
Format: Article
Language:English
Subjects:
Cyanoacrylates
Electrospinning
Glues
Hemostatics
Liver
Medical
Nanostructure
Organs
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Summary:Rapid hemostasis of solitary organs is still a big challenge in surgical procedures or after major trauma in both civilians and on the battlefield. Here, we report the first use of an airflow-directed in situelectrospinning method to precisely and homogeneously deposit a medical glue of n-octyl-2-cyanoacrylate (OCA) ultrathin fibers onto a wound surface to realize rapid hemostasis in dozens of seconds. In vivoand in vitroexperiments on pig liver resection demonstrate that the self-assembled electrospun OCA membrane with high strength, good flexibility and integrity is very compact and no fluid seeping is observed even under a pressure of 147 mm Hg. A similar effect has been achieved in an in vivoexperiment on pig lung resection. The results provide a very promising alternative for rapid hemostasis of solitary organs as well as other traumas, providing evidence that the postoperative drainage tube may not be always necessary for surgery in the near future.
ISSN:2040-3364
2040-3372
DOI:10.1039/c4nr01412j