Fast Determination of Ciprofloxacin by Batch Injection Analysis with Amperometric Detection and Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection

We report fast, precise, selective, and sensitive electroanalytical methods for the determination of ciprofloxacin in milk and pharmaceutical samples by batch‐injection analysis with amperometric detection (BIA‐AMP) and by capillary electrophoresis with capacitively‐coupled contactless conductivity...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2014-02, Vol.26 (2), p.432-438
Main Authors: Montes, Rodrigo H. O., Marra, Mariana C., Rodrigues, Monike M., Richter, Eduardo M., Muñoz, Rodrigo A. A.
Format: Article
Language:English
Subjects:
Amperometry
Antibiotic
Boron-doped diamond electrode
Capillarity
Electrical measurements
Electrolytes
Electrophoresis
Mathematical analysis
Milk
Pharmaceuticals
Standard deviation
Tablets
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Summary:We report fast, precise, selective, and sensitive electroanalytical methods for the determination of ciprofloxacin in milk and pharmaceutical samples by batch‐injection analysis with amperometric detection (BIA‐AMP) and by capillary electrophoresis with capacitively‐coupled contactless conductivity detection (CE‐C4D). Both methods required simple sample preparation protocols before analysis (milk samples were just diluted and tablets powdered and dissolved in electrolyte/water). The analytical features of BIA‐AMP and CE‐C4D methods include, respectively, low relative standard deviation values for repetitive measurements (2.8 % and 1.7 %, n=10), low detection limits (0.3 and 5.0 µmol L−1), elevated analytical frequency (80 and 120 h−1) and satisfactory accuracy (based on comparative determinations by HPLC and recovery values for spiked samples).
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201300474