Adsorptive Stripping Voltammetric Determination of Imipramine and Amitriptiline at a Nanoclay Composite Carbon Ionic Liquid Electrode

A new carbon nanocomposite electrode has been designed by incorporation of montmorillonite nanoclay into a carbon ionic liquid electrode for the electrochemical determination of imipramine (IMP) and amitriptyline (AMT). They are expected to accumulate on the electrode surface through the cooperative...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2014-02, Vol.26 (2), p.424-431
Main Authors: Eslami, E., Farjami, F., Aberoomand Azar, P., Saber Tehrani, M.
Format: Article
Language:English
Subjects:
Amitriptiline
Carbon
Carbon ionic liquid electrodes
Drugs
Electrochemistry
Electrodes
Imipramine
IMP
Ionic liquids
Monitoring
Nanoclay
Nanostructure
Stripping
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Summary:A new carbon nanocomposite electrode has been designed by incorporation of montmorillonite nanoclay into a carbon ionic liquid electrode for the electrochemical determination of imipramine (IMP) and amitriptyline (AMT). They are expected to accumulate on the electrode surface through the cooperative interaction of ionic liquid and clay with the drugs. The proposed electrode also possesses attractive electrocatalytic effects towards the drugs especially AMT. Low detection limits of 19 nM for IMP and 24 nM for AMT were achieved. The proposed nanocomposite electrode exhibits good applicability for monitoring IMP and AMT in pharmaceutical formulations and blood serum samples.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201300557