Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients

• Published in: Genetics and molecular research 2014-01, Vol.13 (3), p.7006-7012
• Main Authors: Zhang, Z L, Che, X M, Bai, Z H, Bu, W J, Bai, L, Pei, H H
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Blood Glucose - metabolism; Critical Illness; Diabetes Mellitus - blood; Diabetes Mellitus - diagnosis; Female; Follow-Up Studies; Glycated Hemoglobin A - metabolism; Humans; Hyperglycemia - blood; Hyperglycemia - diagnosis; Male; Middle Aged; Prognosis; Risk Assessment - methods; Risk Assessment - statistics & numerical data; Risk Factors; Time Factors
• ISSN: 1676-5680; 1676-5680
• DOI: 10.4238/2014.January.24.8

Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blood glucose test when they entered the emergency department. If blood glucose was more than 11.1 mM, a GHb test was followed within 24 h. All patients were followed up for 28 days. According to diabetes mellitus (DM) history, GHb value, and outcome of follow-up, patients were divided into different groups, and mortality rates were calculated, respectively. Hyperglycemia was found in 67.44% (437/648) of patients, and 51.49% (225/437) and 48.51% (212/437) had normal and elevated GHb levels, respectively. At the end of the follow-up period, 14 of the normal GHb patients and 32 of the elevated GHb patients died (6.22 and 15.09%, respectively). In the normal GHb group, 53 had a DM history, 23 were newly diagnosed with DM, and 149 had hospital-related hyperglycemia (HRH); the mortality rates were 11.32% (6/53), 8.70% (2/23), and 4.03% (6/149), respectively. In the elevated GHb group, 114 had a DM history, 83 were newly diagnosed with DM, and 15 had HRH; the mortality rates were 13.16% (15/114), 19.27% (16/83), and 6.67% (1/15), respectively. Hyperglycemia and GHb might play important roles in the prognosis and assessment for critical patients, and the prognosis would vary according to the different causes of hyperglycemia.