Role of trace elements (Zn, Sr, Fe) in bone development: Energy dispersive X-ray fluorescence study of rat bone and tooth tissue

Osteoporosis is one of the most common debilitating disease around the world and it is more and more established among young people. There are well known recommendations for nutrition of newborns and children concerning adequate calcium and vitamin D intake in order to maintain proper bone density....

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Published in:BioFactors (Oxford) 2014-07, Vol.40 (4), p.425-435
Main Authors: Maciejewska, Karina, Drzazga, Zofia, Kaszuba, Michał
Format: Article
Language:English
Subjects:
Animals
Bone Development
iron
Iron - metabolism
Mandible - growth & development
Mandible - metabolism
newborn rat bones
Rats, Wistar
Spectrometry, X-Ray Emission
strontium
Strontium - metabolism
Tooth - growth & development
Tooth - metabolism
trace elements
Trace Elements - metabolism
X-ray fluorescence
zinc
Zinc - metabolism
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Summary:Osteoporosis is one of the most common debilitating disease around the world and it is more and more established among young people. There are well known recommendations for nutrition of newborns and children concerning adequate calcium and vitamin D intake in order to maintain proper bone density. Nevertheless, important role in structure and function of a healthy bone tissue is played by an integration between all constituents including elements other than Ca, like trace elements, which control vital processes in bone tissue. It is important from scientific point of view as well as prevention of bone diseases, to monitor the mineralization process considering changes of the concentration of minerals during first stage of bone formation. This work presents studies of trace element (zinc, strontium, and iron) concentration in bones and teeth of Wistar rats at the age of 7, 14, and 28 days. Energy dispersive X‐ray fluorescence (EDXRF) was used to examine mandibles, skulls, femurs, tibiae, and incisors. The quantitative analysis was performed using fundamental parameters method (FP). Zn and Sr concentrations were highest for the youngest individuals and decreased with age of rats, while Fe content was stable in bone matrix for most studied bones. Our results reveal the necessity of monitoring concentration of not only major, but also minor elements, because the trace elements play special role in the first period of bone development. © 2014 BioFactors, 40(4):425–435, 2014
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.1163