HIF-1α Genetic Variants and Protein Expression Confer the Susceptibility and Prognosis of Gliomas

To investigate the role of HIF-1α genetic polymorphism of c. 1772C > T and c. 1790G > A in the incidence and prognosis of gliomas in a Chinese cohort, a total of 387 gliomas patients and 437 age- and sex-matched healthy controls were recruited. The genetic polymorphism of c. 1772C > T and c...

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Bibliographic Details
Published in:Neuromolecular medicine 2014-09, Vol.16 (3), p.578-586
Main Authors: Yi, Liang, Hou, Xuwei, Zhou, Ji, Xu, Lunshan, Ouyang, Qing, Liang, Hong, Zheng, Zhaocong, Chen, Hongjie, Xu, Minhui
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor
Biomedical and Life Sciences
Biomedicine
Brain Neoplasms - epidemiology
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Case-Control Studies
Cell Division
Cell Line, Tumor
Cell Movement
China - epidemiology
Female
Gene Knockdown Techniques
Genetic Predisposition to Disease
Genotype
Glioma - epidemiology
Glioma - genetics
Glioma - pathology
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - genetics
Hypoxia-Inducible Factor 1, alpha Subunit - physiology
Incidence
Internal Medicine
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Proteins - genetics
Neoplasm Proteins - physiology
Neurology
Neurosciences
Original Paper
Phenotype
Polymorphism, Single Nucleotide
Prognosis
Proportional Hazards Models
Risk
RNA, Small Interfering - pharmacology
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Summary:To investigate the role of HIF-1α genetic polymorphism of c. 1772C > T and c. 1790G > A in the incidence and prognosis of gliomas in a Chinese cohort, a total of 387 gliomas patients and 437 age- and sex-matched healthy controls were recruited. The genetic polymorphism of c. 1772C > T and c. 1790G > A was determined. We found that the genotype distribution at c. 1772C > T showed significant difference between patients and controls. Multivariable analyses showed a significantly higher risk for gliomas in 1772TT genotype carriers (odds ratio 2.68, with CC as reference). In addition, we also found a significantly higher risk for grade III + IV gliomas was observed in 1772TT genotype carriers (odds ratio 2.21, with CC as reference). The overall survival rates in patients with 1772TT or 1772CT genotype were markedly lower compared with patients with CC (both P   T polymorphisms may be used as a molecular marker for gliomas occurrence, grades and clinical outcome in gliomas patients.
ISSN:1535-1084
1559-1174
DOI:10.1007/s12017-014-8310-1