A claudin 3 and claudin 4-targeted Clostridium perfringens protoxin is selectively cytotoxic to PSA-producing prostate cancer cells

Highlights • Prostate cancer cells over-express CPE-toxin receptors CLDN3 and CLDN4. • A protoxin was constructed that is PSA-protease-activated. • The protoxin was selectively cytotoxic to PSA-secreting cells. • The protoxin is a prototype for highly targeted prostate cancer therapy.

Saved in:
Bibliographic Details
Published in:Cancer letters 2014-09, Vol.351 (2), p.260-264
Main Authors: Romanov, Victor, Whyard, Terry C, Waltzer, Wayne C, Gabig, Theodore G
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Cell Line, Tumor
Claudin-3 - genetics
Claudin-3 - metabolism
Claudin-4 - genetics
Claudin-4 - metabolism
Claudins
Cloning, Molecular
Clostridium perfringens
Clostridium perfringens - metabolism
Clostridium perfringens enterotoxin
Enterotoxins - genetics
Enterotoxins - pharmacokinetics
Enterotoxins - pharmacology
Hematology, Oncology and Palliative Medicine
Humans
Kallikreins - biosynthesis
Male
Molecular Sequence Data
Molecular Targeted Therapy
Prostate cancer
Prostate specific antigen
Prostate-Specific Antigen - biosynthesis
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - genetics
Prostatic Neoplasms - metabolism
Protoxin
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - pharmacokinetics
Recombinant Fusion Proteins - pharmacology
Transfection
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Prostate cancer cells over-express CPE-toxin receptors CLDN3 and CLDN4. • A protoxin was constructed that is PSA-protease-activated. • The protoxin was selectively cytotoxic to PSA-secreting cells. • The protoxin is a prototype for highly targeted prostate cancer therapy.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.06.009