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A claudin 3 and claudin 4-targeted Clostridium perfringens protoxin is selectively cytotoxic to PSA-producing prostate cancer cells

Highlights • Prostate cancer cells over-express CPE-toxin receptors CLDN3 and CLDN4. • A protoxin was constructed that is PSA-protease-activated. • The protoxin was selectively cytotoxic to PSA-secreting cells. • The protoxin is a prototype for highly targeted prostate cancer therapy.

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Published in:	Cancer letters 2014-09, Vol.351 (2), p.260-264
Main Authors:	Romanov, Victor, Whyard, Terry C, Waltzer, Wayne C, Gabig, Theodore G
Format:	Article
Language:	English
Subjects:	Amino Acid Sequence Cell Line, Tumor Claudin-3 - genetics Claudin-3 - metabolism Claudin-4 - genetics Claudin-4 - metabolism Claudins Cloning, Molecular Clostridium perfringens Clostridium perfringens - metabolism Clostridium perfringens enterotoxin Enterotoxins - genetics Enterotoxins - pharmacokinetics Enterotoxins - pharmacology Hematology, Oncology and Palliative Medicine Humans Kallikreins - biosynthesis Male Molecular Sequence Data Molecular Targeted Therapy Prostate cancer Prostate specific antigen Prostate-Specific Antigen - biosynthesis Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Protoxin Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacokinetics Recombinant Fusion Proteins - pharmacology Transfection
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description	Highlights • Prostate cancer cells over-express CPE-toxin receptors CLDN3 and CLDN4. • A protoxin was constructed that is PSA-protease-activated. • The protoxin was selectively cytotoxic to PSA-secreting cells. • The protoxin is a prototype for highly targeted prostate cancer therapy.
doi_str_mv	10.1016/j.canlet.2014.06.009
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ispartof	Cancer letters, 2014-09, Vol.351 (2), p.260-264
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subjects	Amino Acid Sequence Cell Line, Tumor Claudin-3 - genetics Claudin-3 - metabolism Claudin-4 - genetics Claudin-4 - metabolism Claudins Cloning, Molecular Clostridium perfringens Clostridium perfringens - metabolism Clostridium perfringens enterotoxin Enterotoxins - genetics Enterotoxins - pharmacokinetics Enterotoxins - pharmacology Hematology, Oncology and Palliative Medicine Humans Kallikreins - biosynthesis Male Molecular Sequence Data Molecular Targeted Therapy Prostate cancer Prostate specific antigen Prostate-Specific Antigen - biosynthesis Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Protoxin Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacokinetics Recombinant Fusion Proteins - pharmacology Transfection
title	A claudin 3 and claudin 4-targeted Clostridium perfringens protoxin is selectively cytotoxic to PSA-producing prostate cancer cells
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