Metabolically-Healthy Obesity and Coronary Artery Calcification

Objectives The purpose of this study was to compare the coronary artery calcium (CAC) scores of metabolically-healthy obese (MHO) and metabolically healthy normal-weight individuals in a large sample of apparently healthy men and women. Background The risk of cardiovascular disease among obese indiv...

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Published in:Journal of the American College of Cardiology 2014-06, Vol.63 (24), p.2679-2686
Main Authors: Chang, Yoosoo, MD, Kim, Bo-Kyoung, MD, Yun, Kyung Eun, MD, PhD, Cho, Juhee, PhD, Zhang, Yiyi, PhD, Rampal, Sanjay, MD, Zhao, Di, MHS, Jung, Hyun-Suk, MD, Choi, Yuni, BS, Ahn, Jiin, MSPH, Lima, João A.C., MD, Shin, Hocheol, MD, PhD, Guallar, Eliseo, MD, DrPH, Ryu, Seungho, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Age
Alcohol use
Biological and medical sciences
Blood pressure
Body mass index
Cardiology
Cardiology. Vascular system
Cardiovascular
cardiovascular disease
Cholesterol
College graduates
Confidence intervals
coronary artery calcium score
coronary artery disease
Coronary Artery Disease - diagnosis
Coronary Artery Disease - epidemiology
Coronary Artery Disease - metabolism
Cross-Sectional Studies
Education
Exercise
Female
Glucose
Health Status
Heart
Homeostasis
Hospitals
Humans
Hypertension
Insulin
Insulin resistance
Internal Medicine
Lipoproteins
Male
Medical sciences
Mens health
Metabolic diseases
metabolically-healthy obesity
Middle Aged
Obesity
Obesity - diagnosis
Obesity - epidemiology
Obesity - metabolism
Physical fitness
Republic of Korea - epidemiology
Triglycerides
Values
Vascular Calcification - diagnosis
Vascular Calcification - epidemiology
Vascular Calcification - metabolism
Women
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Summary:Objectives The purpose of this study was to compare the coronary artery calcium (CAC) scores of metabolically-healthy obese (MHO) and metabolically healthy normal-weight individuals in a large sample of apparently healthy men and women. Background The risk of cardiovascular disease among obese individuals without obesity-related metabolic abnormalities, referred to as MHO, is controversial. Methods We conducted a cross-sectional study of 14,828 metabolically-healthy adults with no known cardiovascular disease who underwent a health checkup examination that included estimation of CAC scores by cardiac tomography. Being metabolically healthy was defined as not having any metabolic syndrome component and having a homeostasis model assessment of insulin resistance 
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2014.03.042