The vaccine efficacy of recombinant duck enteritis virus expressing secreted E with or without PrM proteins of duck tembusu virus

Highlights • The duck tembusu virus (DTMUV) that causes egg-drop has been affecting ducks in China. • No vaccine is currently available for this disease. • A live attenuated duck enteritis virus (DEV) vaccine is widely used in ducks. • A recombinant DEV expresses both the TE and PrM proteins of DTMU...

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Bibliographic Details
Published in:Vaccine 2014-09, Vol.32 (41), p.5271-5277
Main Authors: Chen, Pucheng, Liu, Jinxiong, Jiang, Yongping, Zhao, Yuhui, Li, Qimeng, Wu, Li, He, Xijun, Chen, Hualan
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal diseases
Animals
Antibiotics
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Antigens
Applied microbiology
Aquatic birds
Avian flu
Biological and medical sciences
Coronavirus
Deoxyribonucleic acid
DNA
Ducks - immunology
Eggs
Flavivirus
Flavivirus Infections - prevention & control
Flavivirus Infections - veterinary
Fundamental and applied biological sciences. Psychology
Gene expression
Genomes
Herpesvirus
Infections
Laboratory animals
Microbiology
Mortality
Neutralization Tests
Poultry Diseases - prevention & control
Poultry Diseases - virology
Proteins
Public health
Tembusu virus
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Attenuated - immunology
Viral Envelope Proteins - immunology
Viral Vaccines - immunology
Viruses
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Summary:Highlights • The duck tembusu virus (DTMUV) that causes egg-drop has been affecting ducks in China. • No vaccine is currently available for this disease. • A live attenuated duck enteritis virus (DEV) vaccine is widely used in ducks. • A recombinant DEV expresses both the TE and PrM proteins of DTMUV were constructed. • The recombinant rDEV-PrM/TE vaccination prevents DTMUV infection in ducks.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.07.082