Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue

Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2014-07, Vol.12 (28), p.5235-5242
Main Authors: Scuotto, M, Persico, M, Bucci, M, Vellecco, V, Borbone, N, Morelli, E, Oliviero, G, Novellino, E, Piccialli, G, Cirino, G, Varra, M, Fattorusso, C, Mayol, L
Format: Article
Language:English
Subjects:
Antithrombins - chemical synthesis
Antithrombins - chemistry
Aptamers, Nucleotide - chemical synthesis
Aptamers, Nucleotide - chemistry
Circular Dichroism
G-Quadruplexes
Models, Molecular
Molecular Mimicry
Nucleosides - chemistry
Optical Rotation
Stereoisomerism
Thermodynamics
Thrombin - antagonists & inhibitors
Thrombin - chemistry
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Description
Summary:Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob00149d