Characterization of the immune response in human paracoccidioidomycosis

Summary Objectives Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis that presents two main clinical forms: the adult form (AF) and the juvenile form (JF); and an asymptomatic form denominated PCM-infection (PI). These forms of PCM are re...

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Bibliographic Details
Published in:The Journal of infection 2013-11, Vol.67 (5), p.470-485
Main Authors: de Castro, Lívia Furquim, Ferreira, Maria Carolina, da Silva, Rosiane Maria, Blotta, Maria Heloisa de Souza Lima, Longhi, Larissa Nara Alegrini, Mamoni, Ronei Luciano
Format: Article
Language:English
Subjects:
Adaptative immune response
Analysis of Variance
Biological and medical sciences
Blastomycoses and paracoccidioidomycosis
Case-Control Studies
Cohort Studies
Cytokines
Cytokines - immunology
General aspects
Human mycoses
Humans
Infectious Disease
Infectious diseases
Medical sciences
Mycoses
Paracoccidioides brasiliensis
Paracoccidioidomycosis
Paracoccidioidomycosis - immunology
Paracoccidioidomycosis - pathology
T-Lymphocytes, Helper-Inducer - immunology
Th1
Th1 Cells - immunology
Th17
Th17 Cells - immunology
Th2
Th2 Cells - immunology
Tropical mycoses
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Summary:Summary Objectives Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis that presents two main clinical forms: the adult form (AF) and the juvenile form (JF); and an asymptomatic form denominated PCM-infection (PI). These forms of PCM are related to the immune response developed after infection, which has been associated with Th1 and Th2 responses. However, some PCM characteristics cannot be explained by this balance. In this study we aimed to complement the characterization of the immune response in PCM, including the newly described T cells subpopulations (Th17, Th9 and Th22). Methods We analyzed the expression of cytokines and transcription factors characteristics of these different subpopulations of CD4+ T cells in PBMCs from PCM patients and a PI group. Results The results showed that the PI group presented a predominant Th1 response; that JF patients were characterized by a mixed Th2/Th9 response; and AF patients were characterized by a predominant Th17/Th22 response, as well as substantial participation of Th1 cells. Conclusions These results contribute to the existing knowledge on the immune responses associated with resistance or susceptibility to the P. brasiliensis infection, and thus could lead to the development of new strategies for patient management.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2013.07.019