Oxidative stress in children and adolescents with anxiety disorders

Abstract Background Anxiety disorders are common in children and adolescents, and they can significantly impair quality of life. Genetic, neurobiological, neurochemical, and psychological factors are believed to play a role in the etiopathogenesis of anxiety disorders. Recent evidence suggests that...

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Bibliographic Details
Published in:Journal of affective disorders 2014-03, Vol.156, p.62-66
Main Authors: Guney, Esra, Fatih Ceylan, Mehmet, Tektas, Aysegul, Alisik, Murat, Ergin, Merve, Goker, Zeynep, Senses Dinc, Gulser, Ozturk, Onder, Korkmaz, Alperen, Eker, Sevda, Kizilgun, Murat, Erel, Ozcan
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Adult and adolescent clinical studies
Antioxidants - analysis
Anxiety disorders
Anxiety Disorders - blood
Anxiety Disorders - physiopathology
Biological and medical sciences
Child
Children
Cross-Sectional Studies
Diagnostic performance
Female
Humans
Male
Medical sciences
Mood disorders
Neurochemicals
Oxidants - blood
Oxidative Stress
Oxidative stress index
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Quality of life
Total antioxidative status
Total oxidative status
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Summary:Abstract Background Anxiety disorders are common in children and adolescents, and they can significantly impair quality of life. Genetic, neurobiological, neurochemical, and psychological factors are believed to play a role in the etiopathogenesis of anxiety disorders. Recent evidence suggests that the pathophysiology of anxiety disorders may be associated with oxidative stress. In this study, we investigated whether there are associations between children with anxiety disorders and total oxidant/antioxidant status. Methods The experimental group consisted of 40 patients (children and adolescents) with anxiety disorders. An age- and gender-matched control group composed of 35 healthy subjects was also assessed. Venous blood samples were collected and total antioxidative status (TAS), total oxidative status (TOS), and the oxidative stress index (OSI) were determined. Results Both the TOS and the OSI of the experimental group were significantly higher than those of the control group. There were no significant differences in TAS between the experimental and control groups. Limitations The main limitation of our study was the small sample size. Conclusions This study suggests that oxidative balance is impaired in children with anxiety disorders. Oxidative stress may play a role in the etiopathogenesis of anxiety disorders, and TOS may be a useful diagnostic tool in this context.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2013.11.016