Epigenetic modulators from “The Big Blue”: A treasure to fight against cancer

Highlights • Deregulation of the epigenetic machinery is a hallmark of cancer. • Natural marine compounds possess epigenetic modulatory activities. • Natural marine compounds provide potent anti-cancer drugs. • Epigenetic activity of largazole, psammaplin, trichostatin, azumamide are described....

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Bibliographic Details
Published in:Cancer letters 2014-09, Vol.351 (2), p.182-197
Main Authors: Schnekenburger, Michael, Dicato, Mario, Diederich, Marc
Format: Article
Language:English
Subjects:
Animals
Anti-cancer drugs
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Aquatic Organisms - chemistry
Biological Products - chemistry
Biological Products - pharmacology
Cancer therapies
DNA Methylation
Epigenetic
Epigenetics
Epigenomics
Hematology, Oncology and Palliative Medicine
Histone modifications
Humans
Kinases
Micro-RNAs
MicroRNAs - genetics
Natural marine compounds
Neoplasms - drug therapy
Neoplasms - genetics
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Summary:Highlights • Deregulation of the epigenetic machinery is a hallmark of cancer. • Natural marine compounds possess epigenetic modulatory activities. • Natural marine compounds provide potent anti-cancer drugs. • Epigenetic activity of largazole, psammaplin, trichostatin, azumamide are described.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.06.005