Congenital transmission of Neospora caninum in white-tailed deer (Odocoileus virginianus)

Neosporosis is an important cause of bovine abortion worldwide. Many aspects of transmission of Neospora caninum in nature are unknown. The white-tailed deer (Odocoileus virginianus) is considered one of the most important wildlife reservoirs of N. caninum in the USA. During the hunting seasons of 2...

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Bibliographic Details
Published in:Veterinary parasitology 2013-09, Vol.196 (3-4), p.519-522
Main Authors: Dubey, J.P., Jenkins, M.C., Kwok, O.C.H., Ferreira, L.R., Choudhary, S., Verma, S.K., Villena, I., Butler, E., Carstensen, M.
Format: Article
Language:English
Subjects:
agglutination tests
Animals
antibodies
Antibodies, Protozoan
bioassays
Biological Assay
brain
cell culture
Coccidiosis - parasitology
Coccidiosis - veterinary
Congenital
dams (mothers)
Deer
disease reservoirs
disease transmission
DNA
Female
fetus
Fetus - parasitology
Immunohistochemistry - veterinary
Infectious Disease Transmission, Vertical - veterinary
Mice
Neospora
Neospora agglutination test
Neospora caninum
neosporosis
Odocoileus virginianus
polymerase chain reaction
Pregnancy
Pregnancy Complications, Parasitic - parasitology
Pregnancy Complications, Parasitic - veterinary
tachyzoites
White-tailed deer
wildlife
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Summary:Neosporosis is an important cause of bovine abortion worldwide. Many aspects of transmission of Neospora caninum in nature are unknown. The white-tailed deer (Odocoileus virginianus) is considered one of the most important wildlife reservoirs of N. caninum in the USA. During the hunting seasons of 2008, 2009, and 2010, brains of 155 white-tailed deer fetuses were bioassayed in mice for protozoal isolation. Viable N. caninum (NcWTDMn1, NcWTDMn2) was isolated from the brains of two fetuses by bioassays in mice, and subsequent propagation in cell culture. Dams of these two infected fetuses had antibodies to N. caninum by Neospora agglutination test at 1:100 serum dilution. DNA obtained from culture-derived N. caninum tachyzoites of the two isolates with Nc5 PCR confirmed diagnosis. Results prove congenital transmission of N. caninum in the white tailed deer for the first time.
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2013.03.004