A causal model of post-traumatic stress disorder: disentangling predisposed from acquired neural abnormalities

Highlights • PTSD is triggered by well-delineated stressors, facilitating causal brain models. • Amygdala and dACC abnormalities confer vulnerability for increased fear upon stress. • Reduced hippocampus–vmPFC connectivity following stress may impair fear inhibition. • The functions of these brain c...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cognitive sciences 2013-07, Vol.17 (7), p.337-347
Main Authors: Admon, Roee, Milad, Mohammed R, Hendler, Talma
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
amygdala
Anxiety disorders. Neuroses
Biological and medical sciences
Brain - pathology
Brain - physiopathology
Brain Mapping
Environment
fear extinction
functional connectivity
hippocampus
Humans
Medical sciences
Models, Biological
neuroimaging
Neurology
Post-traumatic stress disorder
prefrontal cortex
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
PTSD
risk factor
stress
Stress Disorders, Post-Traumatic - epidemiology
Stress Disorders, Post-Traumatic - etiology
Stress Disorders, Post-Traumatic - genetics
Stress Disorders, Post-Traumatic - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • PTSD is triggered by well-delineated stressors, facilitating causal brain models. • Amygdala and dACC abnormalities confer vulnerability for increased fear upon stress. • Reduced hippocampus–vmPFC connectivity following stress may impair fear inhibition. • The functions of these brain circuits imply a temporal trajectory of PTSD symptoms.
ISSN:1364-6613
1879-307X
DOI:10.1016/j.tics.2013.05.005