Progressive disseminated histoplasmosis in the HIV population in Europe in the HAART era. Case report and literature review

Introduction In highly endemic areas, up to 20 % of human immunodeficiency virus (HIV)-infected persons will develop progressive disseminated histoplasmosis (PDH). Europe is not endemic to histoplasmosis, and the disease is mainly found in immigrants often co-infected with HIV. Methods We present a...

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Bibliographic Details
Published in:Infection 2014-08, Vol.42 (4), p.611-620
Main Authors: Martin-Iguacel, R., Kurtzhals, J., Jouvion, G., Nielsen, S. D., Llibre, J. M.
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - pathology
Antiretroviral agents
Antiretroviral Therapy, Highly Active - methods
Europe - epidemiology
Family Medicine
General Practice
Histoplasma
Histoplasma - isolation & purification
Histoplasmosis - diagnosis
Histoplasmosis - epidemiology
Histoplasmosis - pathology
HIV Infections - complications
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Immigrants
Infectious Diseases
Internal Medicine
Literature reviews
Lymphocytes
Male
Medicine
Medicine & Public Health
Review
Survival Analysis
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Summary:Introduction In highly endemic areas, up to 20 % of human immunodeficiency virus (HIV)-infected persons will develop progressive disseminated histoplasmosis (PDH). Europe is not endemic to histoplasmosis, and the disease is mainly found in immigrants often co-infected with HIV. Methods We present a case of a patient with HIV and PDH highlighting the possible diagnostic difficulties that may arise in a non-endemic area and review the literature of histoplasmosis in the context of HIV infection with special focus on Europe. Discussion When cellular immunity wanes (usually at CD4 T-lymphocyte counts
ISSN:0300-8126
1439-0973
DOI:10.1007/s15010-014-0611-7