Antibacterial Activities of Persimmon Extracts Relate with Their Hydrogen Peroxide Concentration

Persimmon, a deciduous tree of the family Ebenaceae, is found throughout East Asia and contains high levels of tannins. This class of natural compounds exhibit favorable toxicity profiles along with bactericidal activity without the emergence of resistant bacteria, suggesting potential medical appli...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2014/07/01, Vol.37(7), pp.1119-1123
Main Authors: Arakawa, Hidetoshi, Takasaki, Makiko, Tajima, Noriko, Fukamachi, Haruka, Igarashi, Takeshi
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
antibacterial activity
Bacteria - drug effects
Bacteria - growth & development
chemiluminescence
Colony Count, Microbial
Diospyros - chemistry
Ebenaceae
hydrogen peroxide
Hydrogen Peroxide - analysis
Microbial Sensitivity Tests
persimmon
Plant Components, Aerial - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
reactive oxygen species
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Summary:Persimmon, a deciduous tree of the family Ebenaceae, is found throughout East Asia and contains high levels of tannins. This class of natural compounds exhibit favorable toxicity profiles along with bactericidal activity without the emergence of resistant bacteria, suggesting potential medical applications. Consistent with these observations, persimmon leaves show antibacterial activity. However, the mechanism of persimmon antibacterial activity remains unknown. In the present work, we demonstrate that the antibacterial activity of persimmon reflects the generation of reactive oxygen from tannins. The identification and quantification of reactive oxygen generated from persimmon and the level of antibacterial activity were determined.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b13-00952