Emerging roles of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in cancer progression

Highlights • hnRNP K acts as a docking platform to facilitate molecular interactions. • hnRNP K is involved in transcriptional processes as an activator or a repressor. • hnRNP K and ncRNAs interact to control the expression of target genes. • Tumor cells are characterized by increased levels of hnR...

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Bibliographic Details
Published in:Cancer letters 2014-10, Vol.352 (2), p.152-159
Main Authors: Barboro, Paola, Ferrari, Nicoletta, Balbi, Cecilia
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cancer
Carcinogenesis
Cell Nucleus - metabolism
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Cytoplasm
Cytoplasm - metabolism
Deoxyribonucleic acid
Disease Progression
DNA
DNA methylation
Gene Expression Regulation, Neoplastic
Genes
Hematology, Oncology and Palliative Medicine
Heterogeneous nuclear ribonucleoprotein K
Heterogeneous-Nuclear Ribonucleoprotein K - genetics
Heterogeneous-Nuclear Ribonucleoprotein K - metabolism
Humans
Kinases
Medical prognosis
Molecular weight
Multivariate analysis
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Phosphorylation
Prognosis
Prognostic biomarker
Proteins
RNA polymerase
Transcription, Genetic
Tumors
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Summary:Highlights • hnRNP K acts as a docking platform to facilitate molecular interactions. • hnRNP K is involved in transcriptional processes as an activator or a repressor. • hnRNP K and ncRNAs interact to control the expression of target genes. • Tumor cells are characterized by increased levels of hnRNP K. • hnRNP K aberrant cytoplasmic localization is associated with a worse prognosis.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.06.019