Vaccination with a HSV-2 UL24 mutant induces a protective immune response in murine and guinea pig vaginal infection models

Highlights • Attenuated HSV-2 is a viable approach for genital herpes vaccine development. • An UL24 mutant had reduced virulence in mouse and guinea pig vaginal infection models. • Immunization of mice or guinea pigs with a HSV-2 UL24 mutant was protective.

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Bibliographic Details
Published in:Vaccine 2014-03, Vol.32 (12), p.1398-1406
Main Authors: Visalli, Robert J, Natuk, Robert J, Kowalski, Jacek, Guo, Min, Blakeney, Susan, Gangolli, Seema, Cooper, David
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Applied microbiology
Attenuated vaccine
Biological and medical sciences
Cytokines
Deoxyribonucleic acid
Disease Models, Animal
DNA
Female
Fundamental and applied biological sciences. Psychology
Genes
Genotype & phenotype
Guinea Pigs
Herpes Genitalis - prevention & control
Herpes simplex virus 2
Herpes Simplex Virus Vaccines - immunology
Herpes viruses
Herpesvirus 2, Human - genetics
Herpesvirus 2, Human - pathogenicity
HSV-2
Immune response
Immunity, Cellular
Immunity, Humoral
Immunization
Immunoglobulin G - blood
Infections
Interferon-gamma - immunology
Lymphocytes
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
Mutagenesis, Insertional
Mutation
Studies
Swine
T-Lymphocytes, Cytotoxic - immunology
UL24 mutant
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Attenuated - immunology
Vagina - immunology
Vagina - virology
Viral Proteins - genetics
Virology
Virulence
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Description
Summary:Highlights • Attenuated HSV-2 is a viable approach for genital herpes vaccine development. • An UL24 mutant had reduced virulence in mouse and guinea pig vaginal infection models. • Immunization of mice or guinea pigs with a HSV-2 UL24 mutant was protective.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.10.079