Elevated Serum Levels of Interleukin-17A in Uveitis Patients

Abstract Purpose: T helper 17 cells (Th17) are one of the main pathogenic effectors in autoimmune uveitis, and IL-17A is the signature cytokine of Th17 cells. This study aims to assess serum IL-17A levels in patients with autoimmune uveitis and evaluate associations between IL-17A levels and disease...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2013-12, Vol.21 (6), p.434-439
Main Authors: Jawad, Shayma, Liu, Baoying, Agron, Elvira, Nussenblatt, Robert B., Sen, H. Nida
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Autoimmune Diseases - blood
Autoimmune Diseases - diagnosis
Autoimmune Diseases - immunology
Child
Cytokine
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Immunity, Cellular
interleukin 17
Interleukin-17 - blood
Male
Middle Aged
Retrospective Studies
serum, Th17
Th17 Cells - immunology
uveitis
Uveitis - blood
Uveitis - diagnosis
Uveitis - immunology
Young Adult
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Summary:Abstract Purpose: T helper 17 cells (Th17) are one of the main pathogenic effectors in autoimmune uveitis, and IL-17A is the signature cytokine of Th17 cells. This study aims to assess serum IL-17A levels in patients with autoimmune uveitis and evaluate associations between IL-17A levels and disease characteristics. Methods: Serum IL-17A levels from 87 autoimmune uveitis patients and 60 healthy controls were assessed using an enzyme-linked immunosorbent assay. Among this cohort, 9 patients were followed longitudinally for IL-17A levels during active and inactive stages of their disease. Results: Median serum IL-17A levels were higher among uveitis patients compared to controls (p 
ISSN:0927-3948
1744-5078
DOI:10.3109/09273948.2013.815786